Dynamic restoration and the impact of native versus invasive vegetation on coastal foredune morphodynamics, Lanphere Dunes, California, USA

The Lanphere Dunes, part of the Humboldt Bay National Wildlife Refuge, has been the focus of foredune restoration efforts since the 1980s. Efforts have centred around removal of an invasive European beach grass species, Ammophila arenaria, introduced in the early 1900s to stabilize the dunes to protect landward communities from coastal flooding and storm surges. Despite effectively stabilizing the foredune, A. arenaria forms monotypic vegetation stands, with highly dense roots, rhizomes, and above-ground biomass that can lead to pronounced scarping of the seaward slope, alongshore steering of wind and sediment, a lack of landward transfer of sand, and a steeper, more peaked profile. Effective foredune restoration must consider the coupled interactions between dominant plant type and the geomorphic processes that influence dune form. A 5 ha reach of recently restored foredune was monitored biannually with terrestrial laser scanner and uncrewed aerial systems platforms between 2015 and 2021 to characterize the impacts of dynamic restoration on foredune form and resiliency. This reach included two control plots: (1) native, non-restored and (2) invasive, and three restored plots revegetated with native species: (3) a native grass (Elymus mollis), (4) a low-lying herb and subshrub assemblage, and (5) a mixture of the native grass, herbs, and subshrubs. After five growing seasons, restored plots exhibited distinct geomorphic and sediment budget differences. Natively vegetated plots recovered from extensive scarping 2 years faster than the invasive plot. Restored plots saw foredune height (0.5–0.7 m) and width increase, landward extension (1 m) while maintaining a similar seaward position, and positive lee-slope sediment budgets that exceeded both control plots. These results suggest that the native vegetation plots allowed increased landward sand transport across the foredune, and increased the capacity of the foredune to recover more quickly following dune scarping

GMOS IFU observations of the stellar and gaseous kinematics in the centre of NGC 1068

We present a data cube covering the central 10 arcsec of the archetypal active galaxy NGC 1068 over a wavelength range 4200–5400 Å obtained during the commissioning of the integral field unit (IFU) of the Gemini Multi-object Spectrograph (GMOS) installed on the Gemini-North telescope. The data cube shows a complex emission line morphology in the [O iii] doublet and Hβ line. To describe this structure phenomenologically we construct an atlas of velocity components derived from multiple Gaussian component fits to the emission lines. The atlas contains many features which cannot be readily associated with distinct physical structures. While some components are likely to be associated with the expected biconical outflow, others are suggestive of high velocity flows or disc-like structures. As a first step towards interpretation, we seek to identify the stellar disc using kinematical maps derived from the Mg b absorption line feature at 5170 Å and make associations between this and gaseous components in the atlas of emission line components

ULYSSES, universal LeptogeneSiS equation solver: Version 2

ULYSSES is a Python package that calculates the baryon asymmetry produced from leptogenesis in the context of a type-I seesaw mechanism. In this release, the new features include code which solves the Boltzmann equations for low-scale leptogenesis; the complete Boltzmann equations for thermal leptogenesis applying proper quantum statistics without assuming kinetic equilibrium of the right-handed neutrinos; and, primordial black hole-induced leptogenesis. ULYSSES version 2 has the added functionality of a pre-provided script for a two-dimensional grid scan of the parameter space. As before, the emphasis of the code is on user flexibility, rapid evaluation and is publicly available at https://github.com/earlyuniverse/ulysses

How can onchocerciasis elimination in Africa be accelerated? Modelling the impact of increased ivermectin treatment frequency and complementary vector control

Background: Great strides have been made toward onchocerciasis elimination by mass drug administration (MDA) of ivermectin. Focusing on MDA-eligible areas, we investigated where the elimination goal can be achieved by 2025 by continuation of current practice (annual MDA with ivermectin) and where intensification or additional vector control is required. We did not consider areas hypoendemic for onchocerciasis with loiasis coendemicity where MDA is contraindicated. Methods: We used 2 previously published mathematical models, ONCHOSIM and EPIONCHO, to simulate future trends in microfilarial prevalence for 80 different settings (defined by precontrol endemicity and past MDA frequency and coverage) under different future treatment scenarios (annual, biannual, or quarterly MDA with different treatment coverage through 2025, with or without vector control strategies), assessing for each strategy whether it eventually leads to elimination. Results: Areas with 40%–50% precontrol microfilarial prevalence and ≥10 years of annual MDA may achieve elimination with a further 7 years of annual MDA, if not achieved already, according to both models. For most areas with 70%–80% precontrol prevalence, ONCHOSIM predicts that either annual or biannual MDA is sufficient to achieve elimination by 2025, whereas EPIONCHO predicts that elimination will not be achieved even with complementary vector control. Conclusions: Whether elimination will be reached by 2025 depends on precontrol endemicity, control history, and strategies chosen from now until 2025. Biannual or quarterly MDA will accelerate progress toward elimination but cannot guarantee it by 2025 in high-endemicity areas. Long-term concomitant MDA and vector control for high-endemicity areas might be useful

Assessing potential cluster Cepheids from a new distance and reddening parameterization and 2MASS photometry

A framework is outlined to assess Cepheids as potential cluster members from readily available photometric observations. A relationship is derived to estimate colour excess and distance for individual Cepheids through a calibration involving recently published HST parallaxes and a cleaned sample of established cluster Cepheids. Photometric (V-J) colour is found to be a viable parameter for approximating a Cepheid's reddening. The non-universal nature of the slope of the Cepheid PL relation for BV photometry is confirmed. By comparison, the slopes of the VJ and VI relations seem relatively unaffected by metallicity. A new Galactic Cepheid confirmed here, GSC 03729-01127 (F6-G1 Ib), is sufficiently coincident with the coronal regions of Tombaugh 5 to warrant follow-up radial velocity measures to assess membership. CCD photometry and O--C diagrams are presented for GSC 03729-01127 and the suspected cluster Cepheids AB Cam and BD Cas. Fourier analysis of the photometry for BD Cas and recent estimates of its metallicity constrain it to be a Population I overtone pulsator rather than a Type II s-Cepheid. AB Cam and BD Cas are not physically associated with the spatially-adjacent open clusters Tombaugh 5 and King 13, respectively, the latter being much older (log t ~ 9) than believed previously. Rates of period change are determined for the three Cepheids from archival and published data. GSC 03729-01127 and AB Cam exhibit period increases, implying fifth and third crossings of the instability strip, respectively, while BD Cas exhibits a period decrease, indicating a second crossing, with possible superposed trends unrelated to binarity. More importantly, the observed rates of period change confirm theoretical predictions. The challenges and prospects for future work in this area of research are discussed.Comment: accepted for publication (MNRAS

Expression of Growth Factors and Growth Factor Receptor in Non-healing and Healing Ischaemic Ulceration

AbstractObjectivesTo characterise the histological and cytokinetic characteristics of purely ischaemic ulcers and the processes that underpin healing following successful revascularisation.DesignProspective observational study.Materials and methodsBiopsies were taken immediately pre- and 6 weeks following successful revascularisation of solely ischaemic ulceration. They were evaluated for morphological differences using H&E staining for the platelet derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR), TGFβreceptorIII (TGFβRIII), transforming growth factor beta 1 and 3 (TGFβ1 and TGFβ3) and von Willebrand factor (vWF) expression using immunohistochemistry. Localisation and quantification of these growth factors and receptors was assessed systematically by three independent investigators who were blinded to the timing of biopsy.ResultsPre-operatively, small vessel vasculitis, necrosis and infection with a profuse neutrophil and macrophage infiltrate was observed in all samples. Post-operative biopsies revealed a proliferation of new capillaries in and around the ulcer edge and base. vWF staining confirmed an endothelial layer within these new vessels. Following successful revascularisation there was less infection and inflammation with minimal vasculitis. These newly formed capillaries had increased staining for TGFβ3, PDGFR and TGFβRIII with staining for PDGFR also localised to dermal fibroblasts which were larger and more numerous. Accelerated epithelial cell proliferation was observed with detachment from the underlying dermis.ConclusionsHealing of purely ischaemic ulcers is characterised by vasculogenesis associated with increased presence of the proangiogenic cytokines PDGF and TGFβ3. These findings show promise for the use of growth factor manipulation to aid healing in ischaemic ulcers

TAG: Learning Circuit Spatial Embedding From Layouts

Analog and mixed-signal (AMS) circuit designs still rely on human design expertise. Machine learning has been assisting circuit design automation by replacing human experience with artificial intelligence. This paper presents TAG, a new paradigm of learning the circuit representation from layouts leveraging text, self-attention and graph. The embedding network model learns spatial information without manual labeling. We introduce text embedding and a self-attention mechanism to AMS circuit learning. Experimental results demonstrate the ability to predict layout distances between instances with industrial FinFET technology benchmarks. The effectiveness of the circuit representation is verified by showing the transferability to three other learning tasks with limited data in the case studies: layout matching prediction, wirelength estimation, and net parasitic capacitance prediction.Comment: Accepted by ICCAD 202

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal

The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes proposed by the World Health Organization (WHO) and endorsed by the 2012 London Declaration on Neglected Tropical Diseases (i.e. by 2020/2025). Based on the findings of our previous model comparison, we implemented technical refinements and tested the projections of EPIONCHO and ONCHOSIM against long-term epidemiological data from two West African transmission foci in Mali and Senegal where the observed prevalence of infection was brought to zero circa 2007–2009 after 15–17 years of mass ivermectin treatment. We simulated these interventions using programmatic information on the frequency and coverage of mass treatments and trained the model projections using longitudinal parasitological data from 27 communities, evaluating the projected outcome of elimination (local parasite extinction) or resurgence. We found that EPIONCHO and ONCHOSIM captured adequately the epidemiological trends during mass treatment but that resurgence, while never predicted by ONCHOSIM, was predicted by EPIONCHO in some communities with the highest (inferred) vector biting rates and associated pre-intervention endemicities. Resurgence can be extremely protracted such that low (microfilarial) prevalence between 1% and 5% can be maintained for 3–5 years before manifesting more prominently. We highlight that post-treatment and post-elimination surveillance protocols must be implemented for long enough and with high enough sensitivity to detect possible residual latent infections potentially indicative of resurgence. We also discuss uncertainty and differences between EPIONCHO and ONCHOSIM projections, the potential importance of vector control in high-transmission settings as a complementary intervention strategy, and the short remaining timeline for African countries to be ready to stop treatment safely and begin surveillance in order to meet the impending 2020/2025 elimination targets

The first ALMA view of IRAS 16293-2422: Direct detection of infall onto source B and high-resolution kinematics of source A

Aims: We focus on the kinematical properties of a proto-binary to study the infall and rotation of gas towards its two protostellar components. Methods: We present ALMA Science Verification observations with high-spectral resolution of IRAS 16293-2422 at 220.2 GHz. The wealth of molecular lines in this source and the very high spectral resolution offered by ALMA allow us to study the gas kinematics with unprecedented detail. Results: We present the first detection of an inverse P-Cygni profile towards source B in the three brightest lines. The line profiles are fitted with a simple two-layer model to derive an infall rate of 4.5x10^-5 Msun/yr. This infall detection would rule-out the previously suggested possibility that source B is a T Tauri star. A position velocity diagram for source A shows evidence for rotation with an axis close to the line-of-sight.Comment: Accepted by A&A Letters. 4 pages, 3 figures, 3 appendices (one for Tables, one for additional figures). This second version includes small language modifications and changes to keep the letter within the 4 page limi

In Search of Possible Associations between Planetary Nebulae and Open Clusters

We consider the possibility of cluster membership for 13 planetary nebulae that are located in close proximity to open clusters lying in their lines of sight. The short lifetimes and low sample size of intermediate-mass planetary nebulae with respect to nearby open clusters conspire to reduce the probability of observing a true association. Not surprisingly, line of sight coincidences almost certainly exist for 7 of the 13 cases considered. Additional studies are advocated, however, for 6 planetary nebula/open cluster coincidences in which a physical association is not excluded by the available evidence, namely M 1-80/Berkeley 57, NGC 2438/NGC 2437, NGC 2452/NGC 2453, VBRC 2 & NGC 2899/IC 2488, and HeFa 1/NGC 6067. A number of additional potential associations between planetary nebulae and open clusters is tabulated for reference purposes. It is noteworthy that the strongest cases involve planetary nebulae lying in cluster coronae, a feature also found for short-period cluster Cepheids, which are themselves potential progenitors of planetary nebulae.Comment: Accepted for publication in PASP (December 2007